Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections
نویسندگان
چکیده
منابع مشابه
Ventral tegmental area glutamate neurons: electrophysiological properties and projections.
The ventral tegmental area (VTA) has a central role in the neural processes that underlie motivation and behavioral reinforcement. Although thought to contain only dopamine and GABA neurons, the VTA also includes a recently discovered population of glutamate neurons identified through the expression of the vesicular glutamate transporter VGLUT2. A subset of VGLUT2(+) VTA neurons corelease dopam...
متن کاملElectrophysiological characterization of GABAergic neurons in the ventral tegmental area.
GABAergic neurons in the ventral tegmental area (VTA) play a primary role in local inhibition of mesocorticolimbic dopamine (DA) neurons but are not physiologically or anatomically well characterized. We used in vivo extracellular and intracellular recordings in the rat VTA to identify a homogeneous population of neurons that were distinguished from DA neurons by their rapid-firing, nonbursting...
متن کاملElectrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area.
Coabuse of ethanol and cocaine is one of the most commonly used drug combinations and results in the formation of cocaethylene by the liver. Dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the rewarding properties of drugs of abuse, including ethanol and cocaine. We have previously examined the electrophysiological effects of ethanol and cocaine, and their combined e...
متن کاملVentral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
In addition to dopamine neurons, the ventral tegmental area (VTA) contains GABA-, glutamate- and co-releasing neurons, and recent reports suggest a complex role for the glutamate neurons in behavioural reinforcement. We report that optogenetic stimulation of VTA glutamate neurons or terminals serves as a positive reinforcer on operant behavioural assays. Mice display marked preference for brief...
متن کاملD1 receptors modulate glutamate transmission in the ventral tegmental area.
Perfusion of the D1 agonist, SKF-82958, through a microdialysis probe implanted in the ventral tegmental area produced a dose-dependent increase in extracellular glutamate and GABA. The increase in extracellular glutamate occurred at approximately 30x lower dose than the elevation in GABA. The increase in extracellular glutamate by SKF-82958 was blocked by coperfusion of the D1 antagonist, SCH-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3128-12.2012